Essay on Evolution Lab - 751 Words

1. Did the construction of the phylogenetic tree based on the 14 living Caminalcules change the way you would group Caminalcules species in your taxonomic classification (chart)? What does this suggest about classification based on strictly of similarity versus evolutionary relationship? The phylogenetic tree was more of an evolutionary tree. It showed the evolution of the organisms and their ancestors or traits that they branched off of. The chart however just simply organizes and separates the organisms in similarity. The tree did not change the chart, the chart see similarities with structures between the modern day organisms and the tree shows their evolutionary linage. The tree reflected our taxonomic classification. 2. Did your†¦show more content†¦A good example of this would be â€Å"living fossils† like the horseshoe crab or cockroach. Provide an example from your phylogenic tree of evolutionary stasis. Discuss the ecological conditions that might result in this sort of long-term evolutionary stasis. An example of evolutionary stability would be species 13, the species survived more than 13 million years and now is a â€Å"living fossil†. The ability for the species to reproduce and survive in an area means a there is no need for the species to evolve. Unchanging ecological conditions results in this long term stasis. 6. Some Caminalcules went extinct without leaving descendents. In the real world, what characteristic of a species (not of their enivornment) might increase the probability of a species going extinct? The ecological conditions might have changed quickly and the species was not able to adapt to those conditions, which eventually lead the species to go extinct. 7. Find two examples of convergent evolution among the Caminalcules. This means finding cases where two or more species have a similar characteristic that evolved independently in each lineage. The wings of bats, birds and bees is an example of convergence since the three groups did not inherit the characteristic from their common ancestor. Write your answers in complete sentences (e.g. â€Å"Species x and y both have ____ but their most recent common ancestor, z, did not†). The claws of species 3 and 12 (their most recent common ancestor,Show MoreRelatedEvolution Lab Essay594 Words   |  3 Pagesdocument to report your findings from the EvolutionLab Exploration Experiment. The lab report consists of three sections: Data, Exploration, and Lab Summary. Data: copy any data, graphs, charts, or notes that you have saved in your EvolutionLab online notebook into this section. Exploration: Answer the questions. The questions in the Exploration section are the same questions in your EvolutionLab instructions. Lab Summary: Write a 100- to 200-word summary. Data To copy your data from yourRead MoreEssay about Bio 101 Evolution Lab900 Words   |  4 PagesEvolution Lab BIO/101 Pooja Thakur 7-23-12 Evolution Resulting From Natural Selection INTRODUCTION The Evolution Lab simulates environmental situations to determine effects on evolution over periods of time. This lab experiments with the evolution of finches on two different islands over 100, 200, and 300 years. By manipulating parameters that influence natural selection, the effects that natural selection have on the evolution process can be studied. HYPOTHESES †¢ The sizeRead MoreThe Bioinformatics / Molecular Evolution Lab1243 Words   |  5 PagesThe purpose of the Bioinformatics/Molecular Evolution lab is to explore a particular protein given to us by its amino acid sequence. By entering this protein into the Entrez Protein Database in the National Center for Biotechnology Information, and using tools within this database such as Jpred, SMART, and Protoparm, the given protein could be fully analyzed. This experiment was very successful as our particular protein could be identified, and the tools within the NCBI database allowed us to fullyRead MoreEvolution Lab: The Impact of Drought Conditions on a Finchs Beak Size856 Words   |  3 Pagesrelative percentage of the three levels of hardness changes across a rough continuum. Seed hardness would be predicted to increase finch beak size because more force would be needed to crack open the seeds. This would be an example of directed evolution, because drought conditions will favor one extreme of the finch population, those with larger beak sizes. The bell curve would thus shift in favor of larger beaks. Hypothesis: Drought conditions on Darwin Island will increase the prevalence ofRead MoreEvolution And Natural Selection : The Benefits Of Mutation1321 Words   |  6 PagesEvolution and Natural Selection; The benefits of Mutation Areeba Yousuf Introduction Charles Darwin, a naturalist around the 1800’s , discovered the theory of evolution. He discovered this observation of evolution with his voyages around the world. The specific animals that proved Darwin s theory were the finches he discovered in South America, and then found many variations at many different places. He studies these finches in depth and discovered that they were similar yet somehow different;Read MoreDarwin s Theory Of Biological Evolution1347 Words   |  6 Pagesâ€Å"Evolution refers to the processes that have transformed life on Earth from its earliest forms to the vast diversity that characterizes it today† (Campbell, 1993). However, a lot of things can change over a period of time. The â€Å"Father of Evolution† who is known as Charles Darwin, developed the theory of biological evolution. This theory has long been debated during and after darwin s time. Biological evolution can be seen through a momentous change in organisms by chang ing of the genetic compositionRead MoreIntelligent Design: An Intelligent Way of Disguising Religion1346 Words   |  6 Pagesand Eve have been apes? Evolutionists say humans evolved from apes, but many religious people cannot swallow the thought. For years, religious people have voiced their unhappiness that schools teach evolution. The Bible says that God put all the plants, animals, and people on this planet, and evolution completely contradicts that. The idea of including creationism in schools has been brought to courts multiple times but with no success. Now the creationists have a new way of presenting it. They disguiseRead MoreSex-Linked Traits Through Meiosis and How It Relates to Genetics.1609 Words   |  7 Pagesexamining the hierarchy that ranges from the fundamentals of cell biology to the physiology of organisms, and the interactions among those organisms in their environment. The topics in this course include cell biology, genetics, molecular biology, evolution, ph ysiology, and ecology. Policies Faculty and students/learners will be held responsible for understanding and adhering to all policies contained within the following two documents: †¢ University policies: You must be logged into the studentRead MoreChanges Over A Period Of Time.we1109 Words   |  5 Pages Evolution= Something that changes over a period of time.We can see this more in animals. Fitness= Being physically fit and healthy. For example if gorillas can hit their chest the hardest are the ones that choose their mates first. Natural Selection= Where an organism has to adapt to an environment. They will have to learn to survive and camouflage and who ever survives first has better chances for offspring. Variation= is a change in difference and conditions. Pressure= An organism thatRead MoreGenetic Changes Within The Populations : The Consequences Of Selection1115 Words   |  5 PagesLab Report 1 Genetic Changes in Populations: The Consequences of Selection General Biology II Lab Junyao Li Introduction In this lab, we explore the reason genetic changes happened within a population. We use bean-bag model to simulate allele and genotype frequencies for three generations of deer mice under three different selective regimes. Then, we use the Hardy-Weinberg Principle to assess the selection and evolution experienced by deer mice. The Hardy-Weinberg Principle is one of the most

Rapport de Stage Controle de Gestion /Conseil - 11645 Words

LEBLANC Promotion 2009 Nicolas RAPPORT DE STAGE AIPM Edità © en Fà ©vrier 2008 SOMMAIRE INTRODUCTION 3 1. EUROFINS SCIENTIFIC S.A. 5 1.1 PRESENTATION DE L’ENTREPRISE 5 1.1.1 PRESENTATION DU GROUPE EUROFINS SCIENTIFIC 5 1.1.2 HISTORIQUE DU GROUPE EUROFINS SCIENTIFIC 5 1.1.2.1 Les pà ¨res fondateurs 5 1.1.2.2 Chronologie du dà ©veloppement mondial du groupe 6 1.1.2.3 Eurofins Scientific en chiffres 8 1.1.3 LES ACTIVITES DU GROUPE EUROFINS SCIENTIFIC 9 1.1.4 STRUCTURE ET ORGANISATION DU GROUPE 11 1.1.4.1 Organisation du groupe 11 1.1.4.2 Structure 12 1.2 MA MISSION 13 2. ERNST YOUNG 16 2.1 PRESENTATION DE L’ENTREPRISE 16 2.1.1 HISTOIRE 16 2.1.2 METIERS 17 2.1.2.1 Les mà ©tiers de l’audit 17 2.1.2.2 Les services de†¦show more content†¦Dans ce rapport, je vais vous prà ©senter les deux entreprises que j’ai eu l’occasion de dà ©couvrir, ainsi que les missions qui m’ont à ©tà © confià ©es au sein de ces deux entità ©s. Ainsi, la premià ¨re partie du rapport sera consacrà ©e à   Eurofins Scientific S.A. et au rà ´le que j’ai jouà © au sein de cette entreprise, la deuxià ¨me partie sera dà ©dià ©e à   Ernst Young et aux diffà ©rentes missions auxquelles j’ai pu prendre part. Dans une troisià ¨me partie, je vais analyser les compà ©tences que ces deux stages m’ont permis de dà ©velopper. Pour ce faire, je vais reprendre l’organisation de la grille d’analyse du portfolio des compà ©tences ainsi que les grands verbes dà ©finissants les principales compà ©tences du manager. Bureaux de Ernst Young à   Nantes 1. EUROFINS SCIENTIFIC S.A. 1.1 PRESENTATION DE L’ENTREPRISE 1.1.1 PRESENTATION DU GROUPE EUROFINS SCIENTIFIC Le groupe franà §ais de biotechnologie Eurofins Scientific, fondà © à   Nantes en 1988, est un des premiers groupes mondiaux dans le secteur de la bio analyse. La bio analyse consiste à   pratiquer des tests prà ©ventifs ou descriptifs dans l’agroalimentaire, pour les produits de grande consommation, l’environnement ou la pharmacie. Les tests rà ©pondent le plus souvent à   une nà ©cessità © rà ©glementaire mais aussi à   un souci de protection des marques et de l’image. Les compà ©tences d’Eurofins se situent dans: - l’analyse des produits alimentaires, - les analyses et contrà ´les dans les

Financial Management Questions

Questions: 1. Explain what is meant by the term corporate governance. Recently, a scandal involving Volkswagen was revealed. Based on your knowledge of corporate finance, critically assess what has happened to the value of Volkswagen since the emissions scandal was uncovered. Why do you believe the value has changed and what impact this might have on the corporate governance policies of Volkswagen going forward? How can Volkswagen mitigate the risk of events such as this one occurring in the future? 2. If a bond with a face value of 1,000 and a coupon rate of 7% is currently selling for 1,046, what does that tell you about the current yield to maturity of the bond relative to the bonds coupon rate? Explain why this is the case. Answers: (1). Corporate Governance Corporate governance refers to set of rules, regulations and policies through which the company operated and controlled. It makes sure accountability and transparency by the management of the company with an objective to increase the value of company. It includes action plans, internal controls, and corporate disclosure. It also maintains transparency in operations of a company. Volkswagen (VW) emissions scandal The scandal is related to cheating in emissions tests by VW in the United States (US). In September 2015, Environmental Protection Agency (EPA) discovered that diesel cars being sold by VW in US had device or software which is triggered when the cars are tested and it changes the performance of such cars to satisfy the US emission laws and the engines in these cars emitted nitrogen oxide up to 40 times above than the allowed limit. The event that led to exposing the above scandal is the on-road testing in May 2014 conducted by California Air Resources Board by researchers at West Virginia University. The researchers found that some VW cars emitted almost 40 times the allowed nitrogen oxides when tested on road. Impact on value of Volkswagen since the emissions scandal was uncovered Due to the above scandal following impact was observed on VW VW decided to recall millions of cars across countries Resulted first quarterly loss for 15 years of operations by VW in late October 2015. EPA can also fine the company for $37,500 as maximum for each vehicle that breaches the emission norms which can lead to a maximum fine of $18bn approximately. Chief executive as well as the head of its American operations resigned from their posts and VW also suspended several high-ranked executives. VW stock price took a toll and registered quiet sharp fall in its share prices which led to fall in the market value of the company. VW posted close to $6.2bn loss in 2015 mainly due to above scandal and its associated costs. Impact on corporate governance policies of Volkswagen in future Till the scandal, VW board had a non-independent majority which questions its board integrity and differential voting rights. It was due to its internal guideline which required that half of the directors be employee elected. VW also had large family holdings which compounded the effect of non-independent board. The said scandal may lead to the following impact on corporate governance policies of Volkswagen in future VW may adopt the policy of having more number of independent directors from technical fields which will play a pivotal role in companys operational guidelines. Its internal guideline which required that half of the directors be employee elected may be abolished. VW may adopt more transparent communication methods between management and its stakeholders with regard to its policies regarding various norms by the government of the country in which it is operating and its product offering in those countries. It may also lead to more refined policies with regard to risk management in the company and also with regard to its marketing policies. How can Volkswagen mitigate the risk of events such as this one occurring in the future? To avoid the risk of above much event occurring again in future, VK may adopt following policies in its operations Establish stringent internal control systems which flag the issues and its associated risks in advance. Adopt such marketing policies which are not manipulative or misleading to the potential customers. Delink executive pay from revenues/profits only basis and link it to other performance factors. Create ethical culture and environment in the company between its employees and management. (2). Face Value: 1,000 Coupon Rate: 7% Current Price: 1,046 Yield to maturity (YTM) is the return that the bondholders will earn if the bond is held till its maturity and is based on the coupon rate current price of the bond. In other words YTM is that discount rate at which future payments from bond equals to the current price of the bond. Thus, higher YTM as compared to its coupon rate leads to lower current price and vice versa. (Investopedia) In the given question, Current price of the bond is higher as compared to its face value which signifies that YTM for the bond is lower than the Coupon rate offered on the bond which can be understood as the expectation of the market is of lower interest rates on the specific bond while it is offering a higher coupon rate than expected and thus it is commanding a higher price in the market. References Capital Investment, Capital Investment Appraisal / Appraisal Techniques, viewed on 26 May 2016, Drake, P., Capital budgeting techniques, viewed on 26 May 2016, Finance formulas, Yield to Maturity, viewed on 26 May 2016, Gates, G., Ewing, J., Russell, K. and Watkins, D., Explaining Volkswagens Emissions Scandal, The New York Times, viewed on 26 May 2016, Hotten, R., Volkswagen: The scandal explained, BBC News, viewed on 26 May 2016.

Reform the welfare system an Example of the Topic Government and Law Essays by

Reform the welfare system Reform the welfare system: According to the researches of the Wisconsin university, the main problems of the society is due to a mans individual responsibility, unemployment of most people, family problems, and incapability of having the quality of life ("Child and Family Well-Being"). Need essay sample on "Reform the welfare system" topic? We will write a custom essay sample specifically for you Proceed PROBLEM: Economical dilemma The economical issue of alleviating poverty was addressed by the public policy of the United States during the year of 1930. The first priority is the nuclear unit of a community which is the family, mostly those married couples that have a lot of children to support but are not able to provide for their family (Jackson). Reform Proposal: One-child policy This states that a couple should not have more than one child. It is already one of the policies in china but the interval of it lasts for five years. In this reform, we would lessen the span of time to three years of intervals. In that way the couple will learn more about family planning. In this situation, the couple or parent will be able to provide the most need of the child. They would have enough for food, shelter and clothing unlike when they are providing for a big family. The couple will not have any difficulty in raring an only child (Burns). Evidence: The image below is an example in chinas one child policy. This policy helped prevent the rapid growth of population in china. It then helped prevent the problem of malnutrition in children (Burns). PROBLEM: Being dependent of a single parent with the help of the government is also a one big welfare problem. There are lots of single female parents who are expecting the only help they could get that the AFDC which stands for Aid to Families with Dependent Children could offer them ("Welfare Reform in Pennsylvania "). Reform Proposal: Job employment for single parent Evidence: With this reform, the government will be able to help single parent earn money for their child. The reform will also prevent the people from being dependent from the help that they could get from the other people. The effect of this in the children is that their future will be ensured that they would be able to have a good education when they grew up because the parent can already provide them one (Pasawarat). PROBLEM: Lack of good education Education is one of the peoples basic needs; it will prevent us from being nave. Its why every people should be given the equal right for a good education. Public schools are always competing with the standard of private schools; they are always being questioned about the quality of learning. The basic problem is that the public schools are not fully equipped and does not have enough books to be used by the students for researches ("Education and Child Welfare Program"). Reform Proposal: Totally-free college education with monthly allowance This should be given for those children who are interested to study college but are not able to afford tuition and other school fees. With this reform, a lot of unfortunate people would be given a chance to change their way of living. Evidence: Giving a totally free education will help lessen the burdens of those students who wanted to study that though there are free scholarships, they still could not afford to go to school because they still could not provide money for their other expenses in school. It will also lead children out from being no-knowledge and naivety. This will bring a future that is full of hope for all of the people equally. Work Cited Burns, Alicia. "China's One-Child Policy". 2004. Digital Freedom Network. "Child and Family Well-Being". 2005. Institute of Research on Poverty. April 30 2007. "Education and Child Welfare Program". Reason Public Policy Institute. April 29 2007. Jackson, Robert Max. "Policy Recommendation on Welfare Reform". 2000. New York University. April 29 2007. Pasawarat, John. "Employment and Earnings of Milwaukee County Single Parent Afdc Families: Establishing Benchmarks for Measuring Employment Outcomes Under". 1997. University of Wisconsin Milwaukee.

Princess Bride essays

Princess Bride essays The book starts with explaining Buttercups parents. Her mother nice and sweet, but she often got after her husband for small insignificant things. Her father shuddered at his wife's voice, a hard worker and loving father. They are both talking when they see a huge procession of horses and guards heading towards their home. At first the assume it was their neighbors but then the crowd was past all their neighbors houses and land and going straight towards them. The mother shrieks at her husband that he forgot to pay the taxes and that they were going to be locked up for the rest of their lives and it was all his fault. When the procession arrives out comes the Count and Countess from their carriage. The Count automatically notices Buttercup's beauty and the Countess notices Wesley, his muscles and how young and handsome he is. The Count and Countess say they are interested in how the father raises the cows and feeds them. Because his cows are the best in the land. When they finally leave, the Count tells the Prince about the most beautiful woman in the Village and the Prince is immediately impressed. So one day while Buttercup is out riding her horse, whom she named "Horse," she was approached by the Prince. He told her how beautiful she was and that he wanted to court her and then marry her. She was not impressed, and rode off, she did not know it was the Prince. Yes her and Wesley did fall in love, it was him always bending to her every whim, we all know the famous, "As you wish..." There are some very outstanding differences between the book and the movie though, they kiss and they plan to be wed. But Wesley wants to earn money for his family and wife so he got on a ship and sailed away, he said he would send word as soon as possible. Then when he had enough he would send her a ticket to come be with him. Then he was gone. Buttercup then recived word that the ship he ...

Biography of Olympias, Mother of Alexander the Great

Biography of Olympias, Mother of Alexander the Great Olympias (c. 375–316 BCE) was an ambitious and violent ruler of ancient Greece. She was the daughter of Neoptolemus I, the king of Epirus; the wife of Philip II, who ruled over Macedonia; and the mother of Alexander the Great, who conquered the territory from Greece to northwest India, establishing one of the largest kingdoms of his time. Olympias was also the mother of Cleopatra, the queen of Epirus. Fast Facts: Olympias Known For: Olympias was the queen of Macedonia and the mother of Alexander the Great.Also Known As: Polyxena, Myrtale,  StratoniceBorn: c. 375 BCE in Epirus, Ancient GreeceParents: Neoptolemus I of Epirus, mother unknownDied: c. 316 BCE in Macedonia, Ancient GreeceSpouse: Philip II of Macedonia (m. 357-336 BCE)Children: Alexander the Great, Cleopatra Early Life Olympias was born around 375 BCE, the daughter of Neoptolemus I of Epirus, a Greek king, and an unknown mother. Her family was a powerful one in ancient Greece; they claimed to be descended from the Greek hero Achilles, the main character in Homers Iliad. Olympias was also known by several other names: Polyxena, Myrtale,  and Stratonice. Historians believe she chose the name Olympias to celebrate her husbands victory in the Olympic Games. A follower of mystery religions, Olympias was famed- and feared- for her ability to handle snakes during religious ceremonies. Some scholars believe she belonged to the Cult of Dionysus, a group that worshipped the god of wine, fertility, and religious ecstasy. Reign In 357 BCE, Olympias was married to Philip II, the new king of Macedonia, as a political alliance arranged by her father Neoptolemus, who ruled the Greek kingdom of Epirus. After fighting with Philip- who already had three other wives- and angrily returning to Epirus, Olympias reconciled with Philip at Macedonias capital of Pella and then bore Philip two children, Alexander and Cleopatra, about two years apart. Olympias later claimed that Alexander was actually the son of Zeus. Olympias, as the father of Philips heir presumptive, dominated at court. When the two had been married for about 20 years, Philip married again, this time to a young noblewoman of Macedonia named Cleopatra. Philip seemed to disown Alexander. Olympias and Alexander went to Molossia, where her brother had assumed the kingship. Philip and Olympias publicly reconciled and Olympias and Alexander returned to Pella. But when a marriage of note was offered to Alexanders half-brother Philip Arrhidaeus, Olympias and Alexander may have assumed that Alexanders succession was in doubt. Philip Arrhidaeus, it had been assumed, was not in the line of succession, as he had some kind of mental impairment. Olympias and Alexander tried to substitute Alexander as the groom, alienating Philip. A marriage was eventually arranged between Cleopatra, daughter of Olympias and Philip, to a brother of Olympias. At that wedding, Philip was assassinated. Olympias and Alexander were rumored to have been behind her husbands murder, though whether this is true or not is disputed. Ascension of Alexander After Philips death and the ascension of their son, Alexander, as ruler of Macedonia, Olympias exercised considerable influence and power.  Olympias is alleged to also have had Philips wife (also named Cleopatra) and her young son and daughter killed- followed by Cleopatras powerful uncle and his relatives. Alexander was away frequently  and, during his absences, Olympias assumed a powerful role to protect her sons interests. Alexander left his general Antipater as regent in Macedonia, but Antipater and Olympias frequently clashed. She left and returned to Molossia, where her daughter was now the regent. But eventually Antipaters power weakened and she returned to Macedonia. During his reign, Alexander oversaw the expansion of the Macedonian kingdom, as he conquered the territory from Greece to northwest India. His military skills were unmatched; within a matter of years he was able to conquer the Persian Empire, and he still hoped to make further incursions into Asia when he became sick and died in 323 BCE. Although records indicate that he died of fever, some historians suspect foul play. Battle With Cassander After Alexanders death, Antipaters son Cassander tried to become the new ruler of Macedonia. Olympias married her daughter Cleopatra to a general who contended for the rulership, but he was soon killed in battle. Olympias then tried to marry Cleopatra to yet another possible contender to rule Macedonia. Olympias eventually became the regent for Alexander IV, her grandson (the posthumous son of Alexander the Great by Roxane), and tried to seize control of Macedonia from Cassanders forces. The Macedonian army surrendered without a fight; Olympias had the supporters of Cassander executed, but by then Cassander had escaped. Around this time, Olympias formed an alliance with Polyperchon, Antipaters successor, and Eurydice, the wife of Philip III. The latter provided soldiers for Olympias to command in battle. Cassander maneuvered a surprise attack and Olympias fled; he then besieged Pydna, she fled again, and she finally surrendered in 316 BCE. Cassander, who had promised not to kill Olympias, arranged instead to have Olympias murdered by relatives of the people whom she had executed. Death Following Cassanders orders, relatives of Olympiass victims stoned her to death in 316 BCE. Scholars are not certain whether or not the Macedonian queen was given a proper burial. Legacy Like many powerful figures from ancient history, Olympias lives on in the public imagination. She has been depicted in a variety of books, films, and television series, including the 1956 epic Alexander the Great, Mary Renaults Alexander trilogy, the Oliver Stone film Alexander, and Steven Pressfields The Virtues of War: A Novel of Alexander the Great. Sources Bosworth, A. B.  Conquest and Empire: the Reign of Alexander the Great. Cambridge University Press, 2008.Carney, Elizabeth Donnelly, and Daniel Ogden.  Philip II and Alexander the Great: Father and Son, Lives and Afterlives. Oxford University Press, 2010.Carney, Elizabeth Donnelly.  Olympias: Mother of Alexander the Great. Routledge, 2006.Waterfield, Robin.  Dividing the Spoils: the War for Alexander the Greats Empire. Oxford University Press, 2013.

Analysing your diet using diet plan 6 Essay Example | Topics and Well Written Essays - 750 words

Analysing your diet using diet plan 6 - Essay Example Other than macronutrients, vitamins have different functions to play in a human body. Vitamins referred to as micronutrients. These include Vitamin C, D, E, B6, B12 etc. Each micronutrient plays respective role in the correct functioning of biological systems. The fact remains that the nutrients, both micro and macro, are absorbed in the body and then transported to the destinations where they are suited for best workability. The absorption of micronutrients takes a number of hours. As soon as the absorption takes place, it can be well noted that these nutrients are transferred into blood vessels. There is always a stored amount of nutrients in human body which would make sure that they are recovered during the days when the amount of nutrient (specific) is less. Also, micronutrients are basically water soluble which means that the transfer of these nutrients to other organs would be helping human body to reduce deficiency in a lesser duration. Method: See Handout Results: Following the stated method, a number of findings were noted regarding the intake of food providing certain rate of energy in the body. The results can be visibly understandable if they are compared with he standardized results of intake i.e. Reference Nutrients Intake (RNI). For instance, by careful dietary analysis, it comes to understanding that energy intake rate must be 2217 Kcal whereas the intake taken by me in a day that compared to the energy standard of RNI was 1271 Kcal. Here, it can be noted that I need to work on this standard as I am having a deficiency of energy. In addition, carbohydrate (g) measure as per the analysis notes to be 336.8 while the intake measurement was 80.8g. This denotes that the amount of carbohydrates being taken by me in a day is lesser than the standard measurement point. Proteins can be considered as the nutrients which I have marked overly different intake measure than the expected one. This is visible from the measurements both standard and my per day consumption (Goestenkors & Day, 2011). The rate of proteins that I undertook in a day is noted be 101.8g while the standard is 45.0g. Similarly, the intake of Fat as marked in the software is 61.9g while standard rate 86.2g. Followed by the rate of Fat intake is the measurement of calcium as per RNI should be 700mg while the intake by me in a day was found out to be 338mg. Furthermore, the measurement of vitamin c was marked as 61 whereas usual intake as per RNI should be 40mg. Nutrients Unit Intake Per day R.N.I Per 100g Energy Kcal 1271 1271 2217 74 Fat g 61.9 61.9 86.2 3.6 Protein g 101.8 101.8 45.0 5.9 Carbohydrates g 80.8 80.8 336.3 4.7 Vitamin C 61 61 40 4 Calcium Ca 388 388 700 23 Table 1: The RNI measures and Daily intake measures Discussion The evaluation that was undertaken in this exercise helped me understand the fact that there are a number of shortcomings that can be noted in my daily routine intake (Hesli & Mills, 1999). The above results have marked it quiet evidentl y that there are some of the nutrients that are relatively lesser in my daily routine. This gives a clear idea that I need to work on the ways which can reduce the deficiency (Amend, et al., 2006). The areas where I have lacked a great deal are merely carbohydrates and energy. In order to make sure that I am coping with the measurement of carbohydrates, I would be eating food that is rich in carbohydrates bananas, brown rice etc (Meleis, 2011). There can be a portion of this food that I can take in a day to make sure that

BUS ECON (You Decide Activity) Assignment Example | Topics and Well Written Essays - 250 words

BUS ECON (You Decide Activity) - Assignment Example The first thing that the government usually does in cases like this is to execute monetary policy, a mandate of the Federal Reserve. It lowers interest rates thereby increasing liquidity and helping customers and businesses get back on foot. However, as many analysts would say this may end up hurting the economy in the long run as it may lead to a rise in inflation, something that was witnessed in 2001 in the U.S (Desai, 2011). On the other hand, the idea of increasing taxes and reduced government spending will hurt the common person. This strategy is bad for the economy as consumers and business people will suffer and economic growth will slow down before it picks up again. Such tough measures are not good for the common man as they only benefit the rich (MacEwan & Miller, 2011). The best approach will be the Federal Reserve to retain the current interest rates and be involved strongly in selling bonds in order to increase the bank reserve requirement. This will lead to increased money supply in the economy, as well as stability of financial institutions (Mullard, 2012). However, the federal monetary policies may not be enough and this necessitates the need for both fiscal and monetary policies to help the economy. Some of the fiscal measures could include increased government spending and lowering of taxes. This will balance the economy as the effects of these decisions will be considerate to consumers, as well as businesses (Desai,

Motorcycle Inustry Essay Example for Free

Motorcycle Inustry Essay Hero Honda launched CBZ 156cc motorcycle . Bajaj launched Kawasaki, Boxer AT CT . Royal enfield launched machismo A350 and lightning 535 . Kinetic engineering ltd launched Brat and kinetic challenger . 2000: There was a entry of new companies like TVS , Yamaha , (Lohia Motors) . Hero Honda launched Joy, Passion , and a remodeled Street. Bajaj launched KB Eliminator , KB Caliber Chroma , KB Aspire and KB Acer . LML came up with Adreno and Energy . Escorts Yamaha launched Crux and TVS Group launched Fiero . 2001: Bajaj launched the Pulsar range . TVS launched Victor 110cc . Yamaha upgraded the Crux version with Crux R. Kinetic engineering launched the GF125 and GF150. Background note:- Indian two wheeler market is divided into three major segments :- India is the 2nd largest user and 3rd largest manufacturer of two wheelers in the world. Bajaj Auto laid the foundation of the Indian two wheelers industry in 1948 by trading in imported Vespa scooters. Change in the Trend: Scooters dominated the Indian market till 1990. Thus till 1990 Bajaj was the undisputed leader in scooter market followed by LML Kinetic . After the Liberalisation , privatization and globalization , many companies entered into joint ventures and technical collaborations with foreign companies lke Honda , Suzuki , Yamaha etc. Due to introduction of 100-cc motorcycles an intersegment shift began to start which resulted in the decline in the sales of the motorcycles. Due to delayed launch of new and advanced scooter models , four stroke scooters prone to skidding risk and vibrations etc the demand for motorcycled went up. This demand was mainly driven by rural and semi-urban comsumers. In 2000 , the motorcycle market was characterized by the presence of sub segments based on price :- The Motorcycle Story:- In 1980’s factors namely high running and maintenance cost , perception that motorcycle is more suitable for rural roads , high price of motorcycle in comparison with mopeds or scooters and the availability of fairly new models of scooter led to a sharp decline in the growth of motorcycle segment. De-licensing in the motorcycle industry in mid-1980’s came to their rescue , and hence there was a healthy growth in the sales figure. In 1990 , motorcycle industry witnessed recession because of rising fuel prices , high input cost and reduced purchasing power due to significant rise in general price level and liquidity crisis in comsumer financing. In 1992 companies suffered big time . Entry of new players in the motorcycle market led to losses or fall in profits. In 1993, launch of 100-cc motorcycles led to a inter-segment shift began to take place and motorcycles sales began to grow as a result of flag in the recession. In 1999 , there was a big shift from demand of scooters to the demand of Motorcycles. This shift was mainly attributed tpo the change in customer’s preference towards fuel-efficient and appealing models, delay in launch of new scooters etc. PESTLE ANALYSIS :- Pestle analysis is a tool that can aid the organization in making strategies which will help them understand the external environment in which they operate now and will operate in the future. PESTLE FLOWCHART PESTLE Political/Legal:- 1. Restrictive policy of the govt. towards the car industry in the pre liberalization era . This indirectly helped the motorcycle industry to develop . 2. Delicensing of the automobile sector in mid 1980’s . This led to the entry of foreign players in the automobile industry 3. Break up of the joint venture between -Escorts Yamaha -TVS Suzuki -Hero Motors Honda Motors Due to these break ups Indian Companies were forced to invest in R D for manufacturing indigenously develop models Economical:- 1. High running and maintenance cost . High price of motorcycles in comparison with scooters or mopeds. Due to this companies had to reduce either the quality or had to increase the price of the motorcycles and this resulted in fall in the sales 2. Rise in fuel price high input , reduced purchasing power. This led to increase in the price level and gradually recession. Sociocultural:- 1. Rise in demand for personal transport. This created a demand for two wheelers in the industry 2. Inefficiency of public transportation system made people dissatisfied with it and they demanded some vehicle that could be economical and cater to their needs. 3. Perception that motorcycle were more suitable for the rural roads Availability of fairly new models of scooters. This led to sharp decline in growth of motorcycles . Technological:- 1. Due to Launch of 100-cc motorcycles there was a Intersegment shift and growth of sales figures of motorcycles. 2. Factors like delayed launch of advance scooter models fear of four stroke scooters being prone to increased skidding risks and vibration contributed in the decline in the demand of scooters.

Symbolism and Theme in William Faulkners A Rose for Emily Essay

Symbolism and Theme in William Faulkner's A Rose for Emily  Ã‚  Ã‚   In William Faulkner's short story "A Rose for Emily," a series of interconnected events collectively represent a single theme in the story. Symbolism is the integral factor involved in understanding the theme. "A Rose for Emily's" dominant theme is the search for love and security, a basic human need which can be met unfavorably in equivocal environments. Faulkner's use of symbolism profoundly develops the theme of the story, bringing to light the issues of morality that arise from a young woman's struggle to find love. Faulkner provides the necessary pieces of symbolism, speckled through out the action of the story, for the reader to assimilate and assemble. Curiously, it is a broken time line that Faulkner follows, that allows him to achieve maximum effect at the end of the story. The placement of the conclusion or denouement at the beginning of the story, allows the curiosity of the reader to become strongly engaged on the character of Emily Grierson. As the narration begins with the funeral of Emily, the juxtaposition of the image received in the opening paragraph, is sharply compared to that of the information found in the third paragraph. Where in the first the town has come to pay respects to a fallen monument, in the third it is learned that she was really, "...a duty, and a care; a sort of hereditary obligation upon the town..." (276). The story progresses through flashbacks, and Emily is heard speaking to the gentlemen representing the Board of Aldermen, and it is noticed that she is wearing a thin gold watch chain. It is not until a lull takes place after the spokesman announces the purpose of their visit, that they then,"... could hear the inv... ...uest for love and security, and Emily has provided this for herself. Whether she knew the process through which she gained it was moral or not remains a mystery whose answer died with her. She sought refuge from the cold, and inhospitable environment of abandonment. She sought to get away from the only life she ever knew. The strategic placement of symbolism in the action of this story, provides vast areas with depth of knowledge from which the theme comes forth. The reader is pulled into character early on, by placing the conclusion up front, and placing the falling action at the end of the story. This creates a greater sense of surprise or shock value, and may even evoke a sense of true pity for Emily from the reader. Work Cited Faulkner, William. â€Å"A Rose for Emily.† Literature for Composition. 4th ed. Ed. Sylvan Barnet, et al. New York: HarperCollins, 1996. Symbolism and Theme in William Faulkner's A Rose for Emily Essay Symbolism and Theme in William Faulkner's A Rose for Emily  Ã‚  Ã‚   In William Faulkner's short story "A Rose for Emily," a series of interconnected events collectively represent a single theme in the story. Symbolism is the integral factor involved in understanding the theme. "A Rose for Emily's" dominant theme is the search for love and security, a basic human need which can be met unfavorably in equivocal environments. Faulkner's use of symbolism profoundly develops the theme of the story, bringing to light the issues of morality that arise from a young woman's struggle to find love. Faulkner provides the necessary pieces of symbolism, speckled through out the action of the story, for the reader to assimilate and assemble. Curiously, it is a broken time line that Faulkner follows, that allows him to achieve maximum effect at the end of the story. The placement of the conclusion or denouement at the beginning of the story, allows the curiosity of the reader to become strongly engaged on the character of Emily Grierson. As the narration begins with the funeral of Emily, the juxtaposition of the image received in the opening paragraph, is sharply compared to that of the information found in the third paragraph. Where in the first the town has come to pay respects to a fallen monument, in the third it is learned that she was really, "...a duty, and a care; a sort of hereditary obligation upon the town..." (276). The story progresses through flashbacks, and Emily is heard speaking to the gentlemen representing the Board of Aldermen, and it is noticed that she is wearing a thin gold watch chain. It is not until a lull takes place after the spokesman announces the purpose of their visit, that they then,"... could hear the inv... ...uest for love and security, and Emily has provided this for herself. Whether she knew the process through which she gained it was moral or not remains a mystery whose answer died with her. She sought refuge from the cold, and inhospitable environment of abandonment. She sought to get away from the only life she ever knew. The strategic placement of symbolism in the action of this story, provides vast areas with depth of knowledge from which the theme comes forth. The reader is pulled into character early on, by placing the conclusion up front, and placing the falling action at the end of the story. This creates a greater sense of surprise or shock value, and may even evoke a sense of true pity for Emily from the reader. Work Cited Faulkner, William. â€Å"A Rose for Emily.† Literature for Composition. 4th ed. Ed. Sylvan Barnet, et al. New York: HarperCollins, 1996.

Muslim leaders in south Asia Essay

Muslim leaders in south Asia and northern Africa both had many issues and difficulties when it came to defining their nationalism as an empire. Both southern Asia and Northern Africa struggled politically, educationally, and religiously to define their nationalism. Both Northern Africa and Southern Asia struggled to define their empires nationalism because of political issues. (4,6). A Muslim Egyptian nationalist is speaking about how the east will never see eye to eye with the west. The Nationalist is saying how Egypt can never create nationalism if his country is at civil war, and cannot see eye to eye and agree on things. (4.) This personal bias is an issue because it is only giving an opinion of an eastern African citizen. A western African citizen could be feeling a complete opposite way about politics. This matters because a western African could have a solution to see eye to eye about politics, and completely fix the problem. It would help to see a document showing the opinion of a western African citizen saying how he feels about the east and the west agreeing on politics. Education was a big factor in South Asia and Southern Africa. (3,1). An educator of an oriental college is saying how people would rather chose to save and adopt Islam then to take in the new British education system. This creates nationalism in a way that Islam is looking for new education that will be better, and more innovative then the eastern education systems such as Great Britain. (1). People are more focused on religious ideologies then the actual educational facts that are shown that says an iaindian Muslim leader who was imprisoned several times for political activism. It defines nationalism by the actual facts instead of faith and religion. (3) I would like to see nationalism in the eyes of someone who is not Muslim or religious to see if they feel the same way about the western education systems. Southern Asia and Northern Africa both used religion and Islamic ideologies  and culture to create and define nationalism. (2,5) The Egyptians wanted to focus on their mother land to be their qibla, which marks the direction of mecca, to which a Muslim turns to pray. Egyptians wanted to focus on patriotism and suppress other ties. Religion helped them to do that. (2.) Ahmad lutfi is the founder of the Egyptian people. This is personal bias because he is the leader and thinks what he wants, and wants his people to d the same thing that he thinks. This creates nationalism because everyone is associating with the same thing within their country. (5) Nationalists want to push their ideology onto the people, this is personal bias. It would be beneficial to see an additional document of a political leader instead of just having one from a religious leader.

History and Literature V.S. Science and Mathematics Essay

Nowadays, students have the rights to choose different subjects they would like to study at university. Some like science subjects can register to study science and mathematics; meanwhile, some will prefer to study about history and literature. Personally, I think that it is more important for every student to take part in history and literature class since these subjects will educate students about the past of history and give them rich sources of culture values. Most importantly, history is all records of the past about our country. Learning this subject, students will know about the historical development process of country, such as, when our country established, how our ancients had defended the enemy bravely. All of those like real evidences to tell us again about their sacrifices for the country’s independence and freedom for the next generations. Knowing thoroughly about history teaches us about the loyalty, and how great the deaths of the last generations are. Today, we do not have to go to battle to fight again the enemy, but it is very important to help country become powerful on the economic battle after long time our country underwent the severe war. If every student understands history of their country, they will recognize the importance of their roles in the common development process of country by studying well and become successful people in the future. That will be grateful awards for those who have commit themselves for country’s liberty in the past. Besides that, literature is also important to learn at university since it is the great cultural materials from the past to now. Unlike history teaches us historical stories, literature educates us about cultural values. Through great verses, or poses, we learn about the beauties around our life, our family, such as the motherhood, neighborhood, and couple love†¦. Whenever I read a nice verse about homeland, I feel very exciting and become loving my homeland more and more. All of them are really the vital â€Å"food† for our mental life which cannot obtain by simply studying equations or algorithms in mathematics. In conclusion, I think history and literature would be put in the curriculum in university since it is very necessary for all of us to know about history of country. Moreover, they also teach us valuable lessons about culture values in life which I sure that if our study is without literature; our culture must be very different and boring.

The Meaning of Okuns Law in Economics

The Meaning of Okuns Law in Economics In economics, Okuns Law describes the relationship between production output and employment. In order for manufacturers to produce more goods, they must hire more people. The inverse is also true. Less demand for goods leads to a decrease in production, in turn prompting layoffs. But in normal economic times, employment rises and falls in direct proportion to the rate of production at a set amount. Who was Arthur Okun? Okuns Law is named for the man who first described it, Arthur Okun (Nov. 28, 1928- March 23, 1980). Born in New Jersey, Okun studied economics at Columbia University, where he received his Ph.D. While teaching at Yale University, Okun was appointed to President John Kennedys Council of Economic Advisors, a position he would also hold under Lyndon Johnson. An advocate of Keynesian economic policies, Okun was a firm believer in using fiscal policy to control inflation and stimulate employment. His studies of long-term unemployment rates led to the publication in 1962 of what became known as Okuns Law. Okun joined the Brookings Institution in 1969 and continued to research and write about economic theory until his death in 1980. He also is credited with defining a recession as two consecutive quarters of negative economic growth. Output and Employment In part, economists care about a nations output (or, more specifically, its Gross Domestic Product) because output is related to employment, and one important measure of a nations well-being is whether those people who want to work can actually get jobs. Therefore, its important to understand the relationship between output and the unemployment rate. When an economy is at its normal or long-run level of production (i.e. potential GDP), there is an associated unemployment rate known as the natural rate of unemployment. This unemployment consists of frictional and structural unemployment but doesnt have any cyclical unemployment associated with business cycles. Therefore, it makes sense to think about how unemployment deviates from this natural rate when production goes above or below its normal level. Okun originally stated that the economy experienced a 1 percentage point increase in unemployment for every 3 percentage point decrease GDP from its long-run level. Similarly, a 3 percentage point increase in GDP from its long-run level is associated with a 1 percentage point decrease in unemployment. In order to understand why the relationship between changes in output and changes in unemployment is not one-to-one, its important to keep in mind that changes in output are also associated with changes in the labor force participation rate, changes in the number of hours worked per person, and changes in labor productivity. Okun estimated, for example, that a 3 percentage point increase in GDP from its long-run level corresponded to a 0.5 percentage point increase in the labor force participation rate, a 0.5 percentage point increase in the hours worked per employee, and a 1 percentage point increase in labor productivity (i.e. output per worker per hour), leaving the remaining 1 percentage point to be the change in the unemployment rate. Contemporary Economics Since Okuns time, the relationship between changes in output and changes in unemployment has been estimated to be about 2 to 1 rather than the 3 to 1 that Okun originally proposed. (This ratio is also sensitive to both geography and time period.) In addition, economists have noted that the relationship between changes in output and changes in unemployment is not perfect, and Okuns Law should generally be taken as a rule of thumb as opposed to as an absolute governing principle since it is mainly a result found in the data rather than a conclusion derived from a theoretical prediction. Sources: Encyclopaedia Brittanica staff. Arthur M. Okun: American Economist. Brittanica.com, 8 September 2014. Fuhrmann, Ryan C. Okuns Law: Economic Growth And Unemployment. Investopedia.com, 12 February 2018. Wen, Yi, and Chen, Mingyu. Okun’s Law: A Meaningful Guide for Monetary Policy? Federal Reserve Bank of St. Louis, 8 June 2012.

7 Benefits That Will Persuade You to Attend an English Spoken Course

7 Benefits That Will Persuade You to Attend an English Spoken Course 7 Benefits That Will Persuade You to Attend an English Spoken Course Nowadays learning the English language Ã'â€"Ã'• trulÃ'Æ' a nÐ µÃ' Ã µÃ'•Ã'•Ã'â€"tÃ'Æ' for everyone. ThÐ µ IntÐ µrnÐ µt hÐ °Ã'• rÐ µÃ °llÃ'Æ' Ã' rÐ µÃ °tÐ µd Ð °n Ã'â€"ntÐ µrÃ' Ã ¾nnÐ µÃ' tÐ µd glÐ ¾bÐ °l community and its unÃ'â€"vÐ µrÃ'•Ð °l language Ã'â€"Ã'• EnglÃ'â€"Ã'•h. It Ã'â€"Ã'• nÐ ¾t unÃ' Ã ¾mmÐ ¾n for the US, CÐ °nÐ °dÃ'â€"Ð °n, AuÃ'•trÐ °lÃ'â€"Ð °n Ð °nd UK businesses to have Ã'•tÐ °ff, partners and Ã' uÃ'•tÐ ¾mÐ µrÃ'• all Ð ¾vÐ µr thÐ µ world. ThÐ µ trÐ °vÐ µl Ã'â€"nduÃ'•trÃ'Æ', Ã'â€"ntÐ µrnÐ °tÃ'â€"Ð ¾nÐ °l Ã'€Ð ¾lÃ'â€"tÃ'â€"Ã' Ã'• Ð °nd media are fully connected with EnglÃ'â€"Ã'•h, so Ã'€Ð µÃ ¾Ã'€lÐ µ have come to the point that they nÐ µÃ µd tÐ ¾ Ã'•Ã'€Ð µÃ °k EnglÃ'â€"Ã'•h mÐ ¾rÐ µ Ð °nd mÐ ¾rÐ µ. No matter whÐ µrÐ µ Ã'Æ'Ð ¾u lÃ'â€"vÐ µ Ð ¾r what Ã'Æ'Ð ¾u do, fluency in English Ã'â€"Ã'• becoming a must to funÃ' tÃ'â€"Ð ¾n Ã'â€"n todays society. Of cou rse there are many ways how one can improve his/her knowledge, but the best choice is to attend an English spoken course. Still don’t think that it is necessary to work at your English? Here are most important evidence to make you sure that English is a must: The International Language As one Ð ¾f thÐ µ most wÃ'â€"dÐ µlÃ'Æ' Ã'•Ã'€Ð ¾kÐ µn languages, English Ã'â€"Ã'• knÐ ¾wn as the Ã'â€"ntÐ µrnÐ °tÃ'â€"Ð ¾nÐ °l language. EvÐ µn in Ã' Ã ¾untrÃ'â€"Ð µÃ'• whÐ µrÐ µ it Ã'â€"Ã'• not thÐ µ Ð ¾ffÃ'â€"Ã' Ã'â€"Ð °l lÐ °nguÐ °gÐ µ, Ã'â€"t Ã'â€"Ã'• becoming mÐ ¾rÐ µ Ã' Ã ¾mmÐ ¾nlÃ'Æ' spoken. Media Now wÐ µ lÃ'â€"vÐ µ Ã'â€"n thÐ µ Media Age, and thÐ µ majority Ð ¾f the information Ã'â€"Ã'• Ã'â€"n English. Most wÐ µbÃ'•Ã'â€"tÐ µÃ'•, magazines, bÐ ¾Ã ¾kÃ'•, vÃ'â€"dÐ µÃ ¾Ã'• and research mÐ °tÐ µrÃ'â€"Ð °lÃ'• Ð °rÐ µ Ã'â€"n EnglÃ'â€"Ã'•h as well. If you use thÐ µ IntÐ µrnÐ µt Ã'â€"n your studies Ð ¾r Ã'€Ð µrÃ'•Ð ¾nÐ °l Ð °ffÐ °Ã'â€"rÃ'•, undoubtedly, Ã'Æ'Ð ¾u have already rÐ µÃ °lÃ'â€"zÐ µd this. Business If Ã'Æ'Ð ¾u have a desire tÐ ¾ dÐ ¾ buÃ'•Ã'â€"nÐ µÃ'•Ã'• glÐ ¾bÐ °llÃ'Æ' or Ð µvÐ µn juÃ'•t in thÐ µ US market in the future, being good at thÐ µ EnglÃ'â€"Ã'•h language wÃ'â€"ll bÐ µ a must fÐ ¾r you tÐ ¾ Ã'•uÃ' Ã' Ã µÃ µd. English-speaking Ã'€Ð µÃ ¾Ã'€lÐ µ have much grÐ µÃ °tÐ µr Ð ¾Ã'€Ã'€Ð ¾rtunÃ'â€"tÃ'â€"Ð µÃ'• for business growth or Ð µvÐ µn for getting a well-paid job. Career CÐ °rÐ µÃ µr opportunities fÐ ¾r people whÐ ¾ Ð °rÐ µ fluÐ µnt in EnglÃ'â€"Ã'•h Ð °rÐ µ muÃ' h mÐ ¾rÐ µ Ð °bundÐ °nt thÐ °n for thÐ ¾Ã'•Ð µ whÐ ¾ Ð °rÐ µ nÐ ¾t. People whÐ ¾ lÃ'â€"vÐ µ in Ã'€Ð ¾Ã ¾r areas of the wÐ ¾rld can Ð µÃ °Ã'•Ã'â€"lÃ'Æ' get hÃ'â€"gh-Ã'€Ð °Ã'Æ'Ã'â€"ng jÐ ¾bÃ'• Ã'â€"n the US just due to knowing English well. Homeworking and wÐ ¾rkÃ'â€"ng Ð ¾nlÃ'â€"nÐ µ Ã'â€"Ã'• bÐ µÃ' Ã ¾mÃ'â€"ng commonplace Ã'â€"n thÐ µ business wÐ ¾rld tÐ ¾dÐ °Ã'Æ'. Most AmÐ µrÃ'â€"Ã' Ã °n Ã' Ã ¾mÃ'€Ð °nÃ'â€"Ð µÃ'• provide people from Ð ¾thÐ µr countries with jobs. English ThÐ ¾Ã'•Ð µ whÐ ¾ want to do business Ð ¾nlÃ'â€"nÐ µ wÃ'â€"ll bÐ µ interested tÐ ¾ knÐ ¾w that over 565 mÃ'â€"llÃ'â€"Ð ¾n of IntÐ µrnÐ µt uÃ'•Ð µrÃ'• are EnglÃ'â€"Ã'•h speakers. ThÐ µ mÐ °jÐ ¾rÃ'â€"tÃ'Æ' Ð ¾f the websites are also in English. Needless tÐ ¾ Ã'•Ð °Ã'Æ', Ã'â€"f Ã'Æ'Ð ¾u wÐ °nt tÐ ¾ Ã' Ã ¾mÃ'€Ð µtÐ µ Ã'â€"n thÐ µ glÐ ¾bÐ °l market, EnglÃ'â€"Ã'•h talking Ã'â€"Ã'• a rÐ µquÃ'â€"rÐ µmÐ µnt, Ð °nd bÃ'Æ' hÐ °vÃ'â€"ng your wÐ µbÃ'•Ã'â€"tÐ µ Ð °vÐ °Ã'â€"lÐ °blÐ µ in EnglÃ'â€"Ã'•h, you wÃ'â€"ll Ã'â€"nÃ' rÐ µÃ °Ã'•Ð µ Ã'Æ'Ð ¾ur rÐ µÃ °Ã' h Ð °nd readership by leaps Ð °nd bÐ ¾undÃ'•. Travelling Even if you Ð °rÐ µ nÐ ¾t interested Ã'â€"n dÐ ¾Ã'â€"ng business glÐ ¾bÐ °llÃ'Æ', you mÐ °Ã'Æ' hÐ °vÐ µ the Ð ¾Ã'€Ã'€Ð ¾rtunÃ'â€"tÃ'Æ' tÐ ¾ trÐ °vÐ µl abroad Ð °t different Ã'€Ð ¾Ã'â€"nts. WhÃ'â€"lÐ µ Ã'â€"t would bÐ µ Ã'â€"mÃ'€Ð ¾Ã'•Ã'•Ã'â€"blÐ µ tÐ ¾ lÐ µÃ °rn Ð µvÐ µrÃ'Æ' language Ð ¾f the country Ã'Æ'Ð ¾u want tÐ ¾ vÃ'â€"Ã'•Ã'â€"t, juÃ'•t knÐ ¾wÃ'â€"ng English wÃ'â€"ll make your trÃ'â€"Ã'€ Ð µnjÐ ¾Ã'Æ'Ð °blÐ µ. Education MÐ ¾Ã'•t Ð ¾f the tÐ ¾Ã'€-rÐ °tÐ µd unÃ'â€"vÐ µrÃ'•Ã'â€"tÃ'â€"Ð µÃ'• Ã'â€"n thÐ µ world are Ã'â€"n EnglÃ'â€"Ã'•h-Ã'•Ã'€Ð µÃ °kÃ'â€"ng Ã' Ã ¾untrÃ'â€"Ð µÃ'• the US, the UK, AuÃ'•trÐ °lÃ'â€"Ð ° Ð °nd CÐ °nÐ °dÐ °. If Ã'Æ'Ð ¾u are Ã' Ã ¾nÃ'•Ã'â€"dÐ µrÃ'â€"ng Ã'•tudÃ'Æ'Ã'â€"ng Ð °brÐ ¾Ã °d, Ã'Æ'Ð ¾u wÃ'â€"ll nÐ µÃ µd tÐ ¾ bÐ µ fluÐ µnt Ã'â€"n English not only to Ã'•tudÃ'Æ' Ã'â€"n thÐ µÃ'•Ð µ universities, but Ð °lÃ'•Ð ¾ tÐ ¾ pass Ð µntry exams as well as to obtain a Ã'€Ð µrmÃ'â€"tion for studying Ã'â€"n thÐ °t Ã' Ã ¾untrÃ'Æ'. Books frÐ ¾m Ð °ll Ð ¾vÐ µr thÐ µ wÐ ¾rld are often trÐ °nÃ'•lÐ °tÐ µd Ã'â€"ntÐ ¾ EnglÃ'â€"Ã'•h, more Ð ¾ftÐ µn thÐ °n Ð °nÃ'Æ' Ð ¾thÐ µr language. All in all, if you often struggle with writing English papers, try our service and get custom written papers online.

Describe the importance of having a sound business continuity plan Essay

Describe the importance of having a sound business continuity plan - Essay Example There are numerous benefits derived from business continuity planning including increasing the ability of the firm in avoiding problems in the business environment to the highest level possible. This is due to business continuity giving the firm a chance to assess current risks and as well as forecast future risks. Business continuity also aid in demonstrating credibility in responding to the customers, as the plans for planning on project implementation and completion are already put in place where disruptions occur (Watters, 2010). Business continuity also aids firms to have a competitive advantage due to the ability to continue and complete projects despite disruptions in the business environment that may affect other firms in the industry. Other benefits of business continuity include enhancing the reputation of the business through the ability to meet projects with or without disruptions. Business continuity enhances the resilience of an organization in times of disruptions on the achievement of set goals and objectives. Business continuity also aids in the development of a proven mechanism for the management of business disruption and protect the brand of the company to the clients (Watters, 2010). In conclusion, business continuity is an important factor of a business as demonstrated by the benefits derived by the company in making plans and mechanisms for the business to undertake when disasters strikes. It ensures the firm minimizes loses and comes out of the disruption with minimum negative impact on the business potential of the

U.S financial crisis Term Paper Example | Topics and Well Written Essays - 1000 words

U.S financial crisis - Term Paper Example It was a steady and gradual pace that caught up that finally brings the entire structure crashing down. Some say that it is already over while others argue that it is far from being so and that it will take years to be able to say the country has rid of it completely. Regardless of these arguments, it is of the most import that causes be analyzed to provide for an effective solution to the ailing financial state of the country. There is of course the palpable difference between the dynamics of the economy years ago to the current intricacies of today’s government laden with globalization and a multifaceted area that encompasses the interlocutory status of a country to many others. The crisis as experienced today can be traced back decades ago to the time of Pres. Ronald Reagan and the heyday of capitalism. This is not a direct attack on the merits of Reaganism but merely serves proof that the way business was done then does not necessarily carry with it its applicability decades after. The sheer size of businesses today renders this trite from the time when it was at its prime efficiency. This ideology as Francis Fukuyama states in his article titled ‘The Fall of America, Inc.’ carries two sacred concepts, â€Å"first, that tax cuts would be self-financing, and second, that financial markets could be self-regulating (p. 26). The demand for the dollar by majority of international traders allowed the government to push over as inconsequential the budget deficit. The latter, as we know it, is the very essence of free-market capitalism. The problem reverts back to the issue of housing in the United States. The 1980’s created a mentality for the need of homeownership as definitive of self-identity among Americans. They have then identified themselves as investors and real property was the trend of investment (Shiller, p. 29). â€Å"In Britain as it was in the United States, it wasn’t just owning a home. It was being a better person† (Karabell,

Explain the concepts of both individual and cultural relativism Essay

Explain the concepts of both individual and cultural relativism - Essay Example Of importance to note is that, at times this concept counters itself and its subsequent argument of what might be perceived as right of wrong could be concluded as baseless (Brooks, 2011). This ethical relativism concept articulates that the perception of what is ethically right is dependent on a given culture. For instance, one culture might believe in cannibalism as being morally right while another culture is against the practice. Needless to say, this concept assists in understanding why certain practices are common in some cultures and not others (Brooks, 2011). Apparently, the concept Utilitarianism argues that action could be defined as morally right or wrong when the consequences are at hand unlike ethical relativism where right or wrong is determined by an individual or culture (Brooks, 2011). Kantian theory is described as one of the best ethical principles as it articulates that human beings have the opportunity to effectively use their reasoning faculty to determine what their obligated to do and do it diligently. Conversely, ethical relativism does not entail actual reasoning on a particular action but simple perception (Brooks, 2011). This contract theory revolves around an agreement that is formed by two differently organized groups of people where responsibilities are assigned to each member of the group. Moreover, limitations and rights about certain issues are defined. In ethical relativism, cultural relativism where society is incorporated does not have limitations and rights, but practices that are perceived morally right or wrong (Brooks, 2011). Actually, divine command theory argues that actions deemed to be moral rightly ought to be equivalent to what God has commanded and that being moral is following what God has commanded unlike Ethical Relativism where an individual or culture decides what is right or wrong (Brooks, 2011). This theory articulates that natural laws that are created as a result of human reasoning could

Human African Trypanosomiasis Treatment

Human African Trypanosomiasis Treatment THE synthesis of novel hydrazone compounds to determine the potential anti-parasitic properties and efficacy in the treatment of Human African Trypanosomiasis. ABSTRACT Human African Trypanosomiasis is caused by two sub-species of trypanosome, Trypanosoma brucei gambiense and Trypanosoma brucei rhodeisense. The protozoan parasite has complex mechanisms to evade immune destruction and hence survives in the host, leading to eventual death without treatment. Treatment such as Suramin and Melarsoprol are limited and have high toxicity, often leading to further complications. Alternative therapies are drastically needed to combat trypanosomal infection, with novel hydrazone compounds currently in development promoting trypanocidal activity. The aims and objectives of this research project include the synthesis of novel hydrazone compounds, with aims of high efficacy and low toxicity, namely against Trypanosoma brucei rhodesiense. This was achieved through a series of reactions, with proton NMR spectra used to confirm the structures of novel hydrazone compounds, and biological screening analysis used to assess the trypanocidal activity in vitro. IC50 valu es were obtained for all hydrazones synthesized, the best results coming from HD1, 9.29 ÂÂ µM, and HD6, 16.18 ÂÂ µM. Overall, the presence of chlorine in the compound typically lowered trypanocidal activity when compared to HD1, which lacked chlorine atoms. Despite other compounds in literature having much lower IC50 values, the results remain promising, demonstrating trypanocidal activity against T. brucei brucei, the infective form of trypanosome that affects animals. Trypanocidal activity against Trypanosoma brucei brucei suggests potential activity against Trypanosoma brucei rhodesiense, signifying the IC50 values obtained from novel hydrazones. Furthermore, the biological properties of hydrazone structures demonstrate the potential to develop additional analogues and derivatives, which could contribute to combatting Trypanosoma brucei rhodesiense infection. Likewise, alternative therapies that can cross the blood-brain-barrier are another interest regarding research i n the field. Trypanosoma brucei rhodesiense proceeds rapidly once an individual has been exposed to the parasite, with severe side effects and high mortality rates. This reinforces the need for better and more effective treatment and management of the disease. Key words: Trypanosomiasis, Trypanosoma brucei rhodesiense, hydrazone, Suramin, Melarsoprol, proton NMR, IC50 values 1.1. Background of Human African Trypanosomiasis Human African Trypanosomiasis (HAT), or African sleeping sickness, is a disease affecting a large proportion of Africa, with a suspected 60 million people at risk (Kennedy, 2013).It is caused by two subspecies of trypanosome, a unicellular and flagellated protozoan parasite, with Trypanosoma brucei rhodesiense (T.b.r) causing East- African sleeping sickness, and Trypanosoma brucei gambiense (T.b.g) causing West-African sleeping sickness. West African sleeping sickness is much more prevalent in terms of the whole continent, with 6228 cases reported in 2013. Incidence has decreased massively since 2000, with 25,865 reported cases, although this figure is suspected to be higher due to unreported disease incidence. It is the causative sub-species in 98% of cases. The other 2% of cases are classified as East-African sleeping sickness, with 86 cases reported in 2013, approximately 88% lower than in 2000 (709 cases reported) (Franco et al., 2014). Despite the low incidence of T.b.r infectio n, symptoms are severe and death occurs in almost all patients without treatment. Treatment for suchinfections are limited and have high toxicity, signifying the need for development. Transmission of the protozoan parasite is via the vector, the tsetse fly. Infections with T.b.r proceed rapidly, with entry of infectious metacyclic trypomastigotes into the human bloodstream, lymphatic system and cerebrospinal fluid (CSF) following the initial bite, where proliferation occurs. The tsetse fly ingests a blood meal from an infected animal, with cattle and ungulates acting as reservoirs (Palmer Wells, 2012), and hence ingests trypomastigotes. Various cell divisions and binary fission occur in the mid-gut of the fly to form procyclic trypomastigotes, and conformational changes occur to allow the trypomastigotes to bind to the salivary epithelia. Once attached, the parasite can once again replicate via asymmetric division (Pepin, 2014) to form metacyclic trypanosomes. It is in this way that a person becomes infected with T.b.r (Langousis Hill, 2014). 1.2. Immunology The causative parasite manifests in hosts due to the evasion of the immune system through antigenic variation, delaying the immune response and therefore allowing the parasite to complete its complex lifecycle (Stijlemans et al., 2016). The parasite expresses variant surface glycoproteins (VSGs) on its cell membrane via a glycophosphatidylinositol anchor to serve as a protective barrier. While the immune response induces antibody development against the VSG being expressed, the parasite can switch VSG due to the large amount of VSG genes the genome possesses. This causes new antibodies to form against the newly expressed VSG, and the parasite continues to change VSGs to avoid destruction. Furthermore, the parasites alter their energy metabolism and internal structure, presenting further issues for the immune system (Stijlemans et al., 2016). T.b.r. is resistant to human trypanosome lytic factors (TLFs) containing apolipoprotein L1 (ApoL1), and this is due to the existence of the seru m resistance protein (SRP) coded for by the SRA gene. This binds to TLF-1 and therefore prevents ApoL1-mediated lysis of the infected parasitic cells (Kennedy, 2013; Bart et al., 2015). Kato et al. noted the upregulation of certain cytokines following T.b.r infection, namely IFN-ÃŽÂ ³, IL-10, IL-6 and TGF-ÃŽÂ ² (Kato et al. 2015). Furthermore, these cytokines may play a key role in the inflammatory immune response. IL-6 and IL-10 were upregulated upon CSF examination of late stage patients, and those with CSF trypanosomes had higher levels of WBCs, positively correlating with IL-6 CSF levels. Despite this, no significant changes in levels of cytokines at different stages in HAT were noted. Both subspecies of trypanosome cause non-specific inflammatory responses, resulting in non-specific symptoms. This demonstrates the difficulty in diagnosis and staging of T.b.r infection, and therefore poses a hindrance in regards to timely treatment (Lamour et al. 2015). 1.3. Symptoms Symptoms, typically manifesting 1-3 weeks after bite, include myalgia, hyperplasia of the lymph nodes and spleen, and weight loss in the haemolymphatic stage, and there is clear central nervous system (CNS) involvement in later stages (Pepin, 2014; Kennedy, 2013). It is in this meningoencephalitic stage where patients often exhibit behavioural and motor disturbances including tremors, speech complications, anxiety, confusion, personality changes and others. Further complications may manifest, including ocular difficulties, acute renal failure, multi-organ failure and chronic lymphocytic meningoencephalitis. Death is highly likely to occur in those who do not receive treatment. Trypanosoma brucei produces an aromatic compound called tryptophol, and this induces sleep in humans. Other complications with sleep include irregular patterns of sleep or interrupted sleep, insomnia during the night and sleepiness during the daytime. 1.4. Current problem Current pharmaceutical treatment including intravenous Suramin or Melarsoprol is ineffective and potentially toxic, with patients suffering with neurological dysfunction and post- treatment reactive encephalopathy. Co-administration with eflornithine and nifurtimox has been used to treat T.b.r infection also, but remains somewhat ineffective. Suramin is provided intravenously as the first line treatment for the haemolymphatic stage of T.b.r infection, however this treatment can lead to side effects such as renal failure, peripheral neuropathy and anaphylactic shock, amongst others. It acts by binding to enzymes in the glycosome and disrupts glycolysis within the trypanosome (Babokhov et al., 2013). Should the parasite cross the blood-brain barrier in the later stages of the disease, the treatment options are toxic and limited to the arsenic compound, Melarsoprol, which acts by disrupting trypanosomal redox mechanisms. Treatment with this can lead to further complications such as post-treatment reactive encephalopathy seen in 10% of patients (Palmer Wells, 2012), subsequently causing comas, seizures and cerebral oedema for example. Co-administration of eflornithine with nifurtimox, a hydrazone of 5-nitro-2-furaldehyde, has been shown to demonstrate trypanocidal activity, and is routinely used to treat T.b.g. It has shown trypanocidal activity against T.b.b in mice, however has been relatively ineffective against T.b.r. Furthermore, although eflourthrine abides Lipinskis rule of five in theory, in practice it is a highly hydrophobic compound, and is therefore unlikely to cross inner membranes once administered (Gilbert, 2014). It is therefore administered intravenously. Due to there being no self-cure for T.b.r, treatment is required for a recovery to be made. Furthermore, many of the drugs developed are only applicable to bloodstream trypomastigotes, rather than those that have crossed the blood-brain barrier (Palmer Wells, 2012). Factors such as this demonstrate the problematic nature of the disease, as well as the need for alternative therapies to combat the infection. 1.5. Current research Currently, novel treatments are in development with the hope that toxicity is reduced and efficacy is increased against trypanosomal parasites, namely T.b.r and T.b.b. To determine whether a proposed therapeutic compound is likely to be membrane permeable and therefore orally bioavailable, the Lipinskis rule of 5 is applied. To be within the limits of the rule means that the compound is orally bioavailable and easily absorbed by the body (Leeson, P. 2012). The rules state that the molecular weight of the compound must be less than 500 Daltons, the lipophilicity value is less than 5, represented as a LogP value, the number of hydrogen bond acceptors must be less than 10, and the number of hydrogen donators must be less than 5. Hydrogen bond acceptors include highly electronegative atoms not bound to a hydrogen atom and with free electrons on its outer shell, including oxygen and nitrogen. In newer literature, fluorine may be considered and counted as a hydrogen acceptor. This contrasts with a hydrogen bond donor, any atom that donates a hydrogen atom that it is bound to break or form a bond. All novel compounds are assessed under these rules to dete rmine properties involved in pharmacokinetics (absorption, distribution, metabolism and excretion). Oral administration is non-invasive, more bioavailable and simpler for patient use, all of which is desirable for a new treatment for T.b.r infection. Furthermore, a compound designed may still be orally bioavailable if a single rule is not adhered to. Benzoxaborole compounds have recently been suggested as a new, novel treatment for Trypanosoma brucei (T.b.r and T.b.g) in vitro, namely SCYX-7158 oxaborole(Jacobs et al., 2011). The orally-active treatment is suggested to have high efficacy for both acute and chronic stages of the disease due to the treatment being permeable to the CNS, and properties such as distribution, metabolism, elimination, absorption and toxicology are apparent in vitro. A viability assay combined different whole cell T. brucei spp.and the novel compound to gain positive results of anti-parasitic activity. This treatment demonstrated concentration-dependency, and most trypanocidal activity came from the first 8 hours of a 24-hour exposure. Furthermore, the irreversibility of trypanocidal activity was noted during a short exposure. In vivo, SCYX-7158 was examined against an infection with T.b.b to monitor passage across the blood-brain barrier, with mice models providing an 80% cure rate over a 7 day-treatmen t. Benzoxaboroles, like hydrazones, have demonstrated anti-cancer, anti-fungal, anti- bacterial, anti-viral, anti-inflammatory and anti-parasitic properties with a low intrinsic toxicity similar to table salt when decomposed (Liu et al., 2014). This is due to the metabolites of benzoxaboroles being found to be boric acid and oxidative deboronation products, both with very low toxicity. Per Lipinskis law, it is an orally bioavailable drug with very low IC50 values ranging from 0.19 to 1.008 ÂÂ µM, demonstrating high trypanocidal activity in vitro. An IC50 value is value is the inhibitory concentration value at which 50% inhibition of target cells has occurred. It is important when comparing the difference in the potency of compounds. A higher value represents less efficacy, with smaller values representing good trypanocidal activity in this case. It is a pharmacokinetic parameter, measuring the relationship between drug target and drug. Other research at the forefront include the development of hydrazone compounds of 5-nitro-2-furaldehyde and adamantine alkanohydrazine (Foscolos et al., 2016). Adamantine and derivatives have been previously shown to have trypanocidal activity, increasing for the more hydrophobic, phenyl and cyclohexyl substituents. These compounds and derivatives demonstrated good trypanocidal activity, approximately 20 times greater than nifurtimox. The lowest IC50 value obtained was 0.386 ÂÂ µM. Following the same study, it was found that in the absence of the nitro group, no trypanocidal activity was demonstrated, highlighting the trypanosomal nitro reductase mechanism these novel compounds work by. In terms of the structure-activity relationship, it was seen that the selectivity of compounds against T. brucei species increased when the distance between the carbonyl group and the adamantine skeleton was increased, with derivatives containing 3-cyclopentyl and 3-phenyl being more biologically active than other compounds. In conjunction, the lipophilicity and conformational structure contributed to the efficacy of these novel compounds, with increased lipophilicity and conformational flexibility promoting trypanocidal activity. 1.6. Aims of research Better pharmaceutical treatments with high efficacy and less lethal side-effects are drastically needed for T.b.r infection. Current research demonstrates the potential use of hydrazone compounds and derivatives in combatting parasitic infections, amongst others. Guidance from project supervisor Dr A Bhambra was given throughout the project regarding the structures of compounds. Hydrazones are defined as having the structure R1R2C = NNH2, the N=H bond is conjugated with a lone pair of electrons on the functional nitrogen atom (Verma et al. 2014). Research suggests hydrazone compounds also demonstrate anticancer, anti-inflammatory and anti-HIV properties, signifying biological variety and the potential to treat other diseases (Verma et al., 2014). It is because of these properties that new hydrazone compounds are in development, with the aim of synthesising novel compounds which demonstrate similar properties when applied against Trypanosoma brucei infection, and hence a potential the rapeutic for T.b.r. 2.1. Chemistry/ experimental synthesis The synthesis of four novel hydrazone compounds of reactants A-D and Pentafluorophenyl hydrazine (PFH) (Figure 3) was performed. All solvents and reactants were commercially available. Reflux condensation reactions with relevant reactant (3 mmol) and PFH (3 mmol) were performed, with continuous heating (oil bath) and stirring of compounds at 100-150 ÂÂ °C approximately. Compounds were separated with ethyl acetate (60 ml) and distilled water (50 ml). Excess magnesium sulphate was added to remove any excess water and products were vacuum filtered. Recrystallization reactions with boiling ethanol (10 ml approximately) not in excess were performed, and compounds were vacuumed down to give final compounds. Thin Layer Chromatography (TLC) analysis was performed for all compounds throughout the stages of experiment to monitor the constituents of the final product. Prior to NMR analysis, compounds were dissolved in chloroform (800 ÂÂ µL) with exception of HD6 (with reactant D), dis solved in DMSO (400 ÂÂ µL). 2.2. Biological Screening Analysis Further viability tests were carried out to assess the trypanocidal activity of each compound. Compounds were sent to the London School of Tropical Medicine for biological screening analysis against T.b.b. Stock drug solutions were prepared in DMSO at 20 mg/ml and further diluted appropriately. All assays were performed with use of 96-well microtiter plates, each well containing 100 ÂÂ µL of parasite culture, and serial dilutions of the compound in triplicate. Wells were incubated at 37ÂÂ °C for 72 hrs in 5% CO2. Control wells contained no compound, and blanks consisted of medium only. Following this, the MIC was determined and assurance of growth in control wells. 20 ÂÂ µL of Alamar Blue was added to wells, and plates were incubated for 2-4 hrs more. Plates were read on Gemini Plate Reader with an excitation wavelength of 530 nm and emission wavelength of 580 nm. Following this, IC50 values were obtained. Four novel hydrazone compounds were synthesised, shown in table 1. The electrophilic carbonyl group of appropriate reactants A-D reacted with the nucleophilic nitrogen (hydrazine portion) of PFH by nucleophilic addition. IC50 values gained demonstrated potential, especially HD1 and HD6. Proton NMR analytical results from spectra obtained are demonstrated below, showing the amount of hydrogens (or protons) in each compound as well as their corresponding intensities. Throughout synthesis, TLC was performed for each compound to visualize the two reactants, the formed product and any other substance that may be present. Rf values and appropriate TLC analysis results are illustrated in alongside compounds in table 1. 3.1. HD1 Beige crystals (50% yield); ÃŽÂ ´H (CDCl3) 7.28 (1H, s), 7.32-7.42 (3H, m), 7.64 (2H, dd), 7.82 (1H, s). 3.2. HD4 Pink crystals (50% yield) ÃŽÂ ´H (CDCl3) 7.30 (2H, s), 7.35 (1H, s), 7.45-7.50 (1H, m), 7.62 (1H, s), 7.73 (1H, s). 3.3. HD5 Beige crystals (H (CDCl3) 7.32-7.38 (3H, s), 7.54-7.60 (2H, d), 7.78 (1H, m). 3.4. HD6 Red crystals (H (CDCl3) 7.37 (1H, s), 7.45 (2H, s), 7.70 (2H, s). 3.5. Biological screening analysis Results obtained from the London School of Tropical Medicine included IC50 values for all hydrazones synthesised. These are listed alongside appropriate compounds in table 1. HD1 had an IC50 value of 9.29 ÂÂ µM; HD4 34.37 ÂÂ µM; HD5 34.09 ÂÂ µM and HD6 16.18 ÂÂ µM. Formation of all compounds HD1, HD4, HD5 and HD6 (table 1) followed the general mechanism illustrated in appendix 1. R1 should be substituted with relevant reactant (A-D) benzene rings. Electrophilic reactants accept free pairs of electrons from the nucleophilic nitrogen atom of PFH by nucleophilic addition. The formation of a biologically active centre was documented (Verma, 2014). All compounds synthesised contain phenyl groups, which has been suggested in literature to promote trypanocidal activity (Foscolos et al., 2016). Hydrazones synthesised are also non-polar and hydrophobic compounds, meaning that they carry no net charge and are not soluble in water. Furthermore, an increase in hydrophobicity also promotes trypanocidal activity, however has been suggested to make the compound less bioavailable (Gilbert et al., 2014). Proton NMR spectra demonstrate relative intensities in parts per million (ppm) of protons or hydrogens in the compound. Despite only hydrogens being of interest, it is important to consider the other electronegative groups that exist within the compound such as phenyl groups or -OH groups, which produce different peaks. The solvent peak demonstrates as a sharp, well distinguished peak to exclude it from the compound results. Singlet, doublet and Name Reactant Structure IC50 value (ÂÂ µM) TLC (illustrated- not to scale) Rf value (cm) HD1 Benzaldehyde (reactant A) 9.29 0.73 HD4 3-chlorobenzaldehyde (reactant B) 34.37 0.48 HD5 4-chlorobenzaldehyde (reactant C) 34.09 0.43 HD6 3,4-dichlorobenzaldehyde (reactant D) 16.42 0.57 multiplet peaks were all demonstrated on the spectra. NMR analysis reflects the structures synthesised, confirming the number and positioning of hydrogens. The spectra observed demonstrated some sharp peaks and others more broad. Furthermore, some peaks were somewhat distorted due to the presence of chlorine on the aromatic benzene ring. Limitations of the experimental synthesis included low yields obtained from synthesised hydrazones. This could have been possibly due to the recrystallization step or some of the reactants not converting into product. Factors such as this could have been improved to gain better results. In addition, yields were estimated due to not weighing compounds beforehand, therefore weighing the compounds when they were initially synthesised would improve the data. 4.1. HD1 From the NMR spectra, HD1 contained 7 hydrogen atoms, one at 7.28 ppm as a singlet peak, three at 7.32 7.42 ppm as a mutliplet peak, two at 7.64 ppm as a doublet peak and one hydrogen at 7.82 ppm as a singlet peak. All novel compounds synthesised differ in terms of the aromatic benzene ring on the relevant reactants, therefore the positioning and amount of chlorine attached to this aromatic ring demonstrates the difference in IC50 values. This coincides with the biological activity against T.b.b. HD1 is formed of benzaldehyde and PFH, and therefore does not possess any chlorine atoms. The IC50 values were the lowest for HD1 at 9.29ÂÂ µM, which suggests that the presence of chlorine in the compound may decrease trypanocidal activity. 4.2. HD4 HD4 contained six hydrogen atoms, two at 7.30 ppm as a singlet peak, one hydrogen at 7.35 ppm as a singlet peak, one hydrogen at 7.45-7.50 ppm as a multiplet peak and a one hydrogen as a singlet peak at 7.73 ppm. HD4 contained a chlorine group on the 3rd carbon of the reactant benzene ring, with displacement of chlorine by (bio)nucleophiles, facilitated by the electrophilic carbon centre determining biological properties observed. However, it has been suggested that the presence of a chlorine atom at a non-reactive aromatic double bond diminishes reactivity (Naumann, 2003). The IC50 value for HD4 was 34.37 ÂÂ µM, the highest value from all the compounds synthesised. This supports the notion that chlorine atoms present in the compound reduces trypanocidal activity rather than improving it. 4.3. HD5 HD5 also contained six hydrogens, with three hydrogens at 7.32 7.38 ppm in a singlet peak, 2 hydrogens at 7.54 7.60 ppm in a doublet peak, and one hydrogen at 7.78 ppm in a multiplet peak. HD5 also contained a chlorine atom but on the forth carbon of the benzene ring, as opposed to the third. Altering the position of the chlorine atom did allow for an improved IC50 value to be obtained, which was 34.09 ÂÂ µM. This however remains much less effective than HD1. 4.4. HD6 HD6 contained five hydrogen atoms, one at 7.37 ppm as a singlet peak, one at 7.35 ppm as a singlet peak, two at 7.45 ppm in a singlet peak, and 2 hydrogens at 7.70 ppm in a singlet peak. Despite the presence of chlorine in both HD4 and HD5 causing less effective activity against T.b.b, HD6 contained two chlorine atoms attached to the benzene ring, and the IC50 value obtained was nearly half that of HD4 and HD5 at 16.18 ÂÂ µM. This suggests that the presence of one chlorine atom existing at any carbon on the benzene ring does not promote trypanocidal activity, however the presence of 2 attached chlorine atoms did aid activity. 4.5. Oral bioavailability Per Lipinskis rule of 5, all novel compounds fall within the laws except from HD1, which contains 6 hydrogen bond donors. HD1 therefore would be more bioavailable if administered intravenously, however may still be orally bioavailable as only one rule has been violated, with the rest all being adhered to. Despite this, the other novel compounds alone demonstrate progression in seeking an orally bioavailable treatment for HAT, linked with reducing toxicity amongst being easier and more accessible for those who require it. Furthermore, the use of PFH incorporates many fluorine atoms, which increases lipophilicity (Citation), increasing activity in vivo, as well as increasing fat solubility and therefore allowing the compounds to easily pass through membranes in the body. Retaining fluorine is a desirable property due to the improvement of metabolic stability as a result of the high strength C-F bond. It is a relatively small molecule, with a high electronegativity value. All properties such as this contribute to biological responses within the body. 4.6. Comparison to literature IC50 values HD1 and HD6 demonstrated the most promising results of 9.29 and 16.18 ÂÂ µM. For comparison intentions, alternative novel therapies at the forefront of science such as adamantine alkanohydrazine hydrazones and benzoxaborole SCYX-7158 have IC50 values of 0.386ÂÂ µM and 0.19 to 1.008ÂÂ µM respectively (Foscolos et al., 2016; Jacobs et al., 2011). Although the results from the synthesised compounds are promising and suggest trypanocidal activity against Trypanosoma brucei, both SCYX-7158 and the adamantine alkanohydrazine hydrazones have much lower IC50 values, suggesting that the structures of novel compounds could be improved and altered to gain better trypanocidal activity. Furthermore, current treatment Melarsoprol and Suramin have IC50 values of 0.046 and 0.004-0.009 ÂÂ µM, much lower than the compounds synthesised (Torreele et al., 2010). However, as stated above, these treatments offer high toxicity and high mortality rates following administration, and the fa ct that the novel compounds synthesised (HD1 especially) have low IC50 values remains promising. Furthermore, both Suramin and Melarsoprol are administered intravenously, posing more problems in terms of accessibility as developing countries where the disease is endemic possibly do not possess the facilities to administer treatment. This is unlike the synthesised hydrazone compounds, which all theoretically can be administered orally, therefore moving towards better treatment and management of T.b.r infection. HD4 and HD5 demonstrate lower trypanocidal activity than HD1 and HD6, therefore further progression on HD1 especially would allow for potentially more effective trypanocidal compounds, represented by lower IC50 values upon testing. Furthermore, new compounds in other literature with the highest trypanocidal activity, namely 5-nitro-2-furaldehyde and adamantine alkanohydrazine hydrazones and benzoxaboroles, provide a platform for future work and development of structural analogues of hydrazones to promote trypanocidal activity. To confirm that the novel compounds synthesised are in fact effective against T.b.r, further testing is required in a controlled level 3 laboratory where the p

The Battle Of Midway Essay -- American History

The Battle of Midway On June 3rd, 1942, the United States declared war on Imperialistic Japan and Nazi Germany. Due to the bombing of the United States' naval base at Pearl Harbor by the Japanese the U.S. was forced to take action. The United States began their first naval battle near the Midway islands in defense of its pacific fleet and positioning. Midway was the Japanese' last goal for its western expansion in the Pacific. Just after midnight on June 4th,1942, the United States attacked a fleet of Japanese transport ships. One American torpedo plane took out fleet tanker "Akabono Maru". Later that morning at about 6:30am, Japanese planes began bombing midway island installations, though causing minimal damage to the U.S. naval base. Between 9:30am and 10:30am the U.S. took out Japanese aircraft carrier's "Kaga, Akagi, and Soryu". During the battle the Japanese recovered three U.S. naval aviators. But after interrogating these men, the Japanese murdered them. On June 5th, 1942, a battleship, under the command of Rear Admiral Spruance, pursued the Japanese fleet westward leaving salvage workers to repair the U.S. aircraft carrier "Yorktown"(which was damaged a day earlier by a Japanese submarine torpedo). The last of the air attacks of the battle took place on June 6th, 1942, with the United States beginning to emerge victorious with the sinking of 2 destroyers, 1 heavy cruiser, and 1 cruiser. Meanwhile a Japanese submarine torpedoed aircraft carrier "Yorktown" and the destroyer "USS Hammann", though it took a day for the carrier to turn over and sink. The Japanese submarine escaped with-out destruction soon after the torpedoing. (Naval Historical Center, Battle of Midway:4-7 June 1942, Department of the Navy... ...he U.S. complete control over the Pacific Ocean. This defeat also gave the Allies an absolute victory over Japan and the remaining Axis powers. The infamous Battle of Midway officially ended on June 7th 1942. Works Cited Baikie, Eric. Ngo, Kevin. Collins, McKenzie. "Major Battles of WWII". Viking Press. January 2002. Bruce, George "Sea Battles of the 20th Century", Stopping the Tide: the Battle of Midway 4th - 7th 1942, Department of the Navy, May 1990 Cressman, Robert, J. "No End Save Victory", Naval Historical Center, June 1998 Dingman, Roger, The origins of naval arms limitation,"Power In The Pacific", Naval Institute Press, 1998. Naval Historical Center, "Battle of Midway: 4th -7th June 1942, Department of the Navy. June, 30, 2003. Naval Historical Center, "Preparation For Battle" Department of the Navy, April 1999

Emile Durkheim – Division of Labor

DIVISION OF LABOR IN SOCIETY The Division of Labor in Society by Emile Durkheim explains how in the modern societies the division of labor affects individuals and society contradicting Marx’s belief that the division of labor will all result to alienation. Durkheim argued that the division of labor is not necessarily â€Å"bad† for it â€Å"increases both the productive capacity and skill of the workman; it is the necessary condition for the intellectual and material development of societies; it is the source of civilization. More importantly, it creates a feeling of solidarity among the people. For Durkheim, the result of Division of Labor is positive for there is no need for competition in the sense of struggling just to survive but the division of labor may signify that there are sufficient material resources for all in the society, and in this division allows a certain form of cooperation and because people need each other this produces a solidarity in the society. *As we noted previously, Marx saw both alienation and class conflict as inevitable (or â€Å"normal†) in capitalist societies.By contrast, rather than seeing social conflict as a â€Å"normal† condition of capitalism, Durkheim maintained that anomie results only in â€Å"abnormal† conditions of overspecialization, when the rules of capitalism become too rigid and individuals are â€Å"forced† into a particular position in the division of labor. *Causes of Division of Labor: division of labor develops regularly as history proceeds. This fact certainly depends on causes that are likewise constant, causes that we shall investigate. † (p. 179). â€Å"THe increase in the DOL is therefore due to the fact that the social segments lose their individuality, that the partitions dividing them become more permeable. IN short, there occurs between them a coalescence that renders the social substance free to enter upon new combinations. † {p. 141} The key to the expansion of the DOL is the increase in social interaction, particularly functional differentiation. * This is what gives moral value to the division of labor. Through it, the individual becomes aware of his dependence upon society; from it come the forces which keep him in check and restrain him.In short, since the division of labor becomes the chief source of social solidarity, it becomes, at the same time, the foundation of the moral order. * Moreover, far from being trammeled by the progress of specialization, individual personality develops with the division of labor. To be a person is to be an autonomous source of action. Man acquires this quality only in so far as there is something in him which is his alone and which individualizes him, as he is something more than a simple incarnation of the generic type of his race and his group.The division of labor itself contributes to this enfranchisement, for individual natures, while specializing, become more complex, and by that are in part freed from collective action and hereditary influences which can only enforce themselves upon simple, general things. The most visible example of social solidarity that Durkheim mentioned was law. Law is the organization of social life in its most stable and precise form. The classification of law depends on the type of solidarity corresponds to it. The first type of law is the repressive law which imposes a fine or injury on the perpetrator.The second one is the restitutory laws which refer to restoring the previous relationship which have been disturbed from before the crime was committed. Repressive law tends to stay diffused througout the society, restitutory law works through more specialized bodies like in courts, magistrates and lawyers. *Despite the removed role of restitutory law from socirty, society still intervenes in restitutory sanctioning. The formation of a contract directly concerns the parties involved: nonetheless, id a contract has a binding forc e, it is a society which confers that force.If society does not give its blessing to the obligations that have been contracted, then these obligations are reduced to only moral promises. Hence the presence of society in restitutory law, although not necessarily felt, is nonetheless essential. negative control – regulations which make a person refrain from acting ex. do not help a farmere with his crop, simply prevent him from stealing his neighbor's positive control – regulations which make a person act ex. impose a certain method of farming upon a farmer. Mechanical Solidarity or solidarity by similarities, it is deeply rooted in everyone doing or feeling the same thing.It is the type of solidarity that is associated with repressive laws that corresponds to crimes resulting in repressive punishments. Durkheim pointed out in his book that how the repressive or penal rules demonstrates the strength of resistance of collective response to a crime. Thus it is now called c ollective consciousness which is the â€Å"totality of beliefs and sentiments common to average citizens of the same society forms a determinate system which has its own life. † Therefore, it is summarized as an act is only criminal if it offends the â€Å"strong, well-defined states of collective consciousness. *Mechanical solidarity is typified by feelings of likeness. Mechanical solidarity is rooted in everyone doing/feeling the same thing. Durkheim maintained that this type of solidarity is characteristic of small, traditional societies. In these â€Å"simple† societies, circumstances compel individuals to be generalists involved in the production and distribution of a variety of goods. Indeed, in small, traditional societies, specialization in one task to the exclusion of others is not possible because the society depends on each individual providing a host of contributions to the group.For instance, men, women, and children are often all needed to pick crops at harvest time, and all partake in the harvest-time celebrations as well. Durkheim argued that a significant social consequence of the shared work experience characteristic of traditional societies is a shared collective conscience. People in traditional societies tend to feel â€Å"one and the same,† and it is this feeling of â€Å"oneness† that is integral in the maintenance of social order. Yet, Durkheim saw that in large, complex societies, this type of solidarity was waning.In large, modern societies, labor is specialized; people do not necessarily all engage in the same work or share the same ideas and beliefs. *â€Å"Since the rules are inscribed upon everyone's consciousness, all are aware of them and feel they are founded upon right. † â€Å"Undoubtedly if an act is punished, it is because it is contrary to a mandatory rule, but this rule is not expressly spelt out. There can be only one reason for this: it is because the rule is known and accepted by ev erybody. † (p. 5) â€Å"we should not say that an act offends the common consciousness because it is criminal, but that it is criminal because it offend that consciousness. † (p. 42) [133] *What separates repressive law from civil law – law that simply restores previous order? First, recall that crimes are those things that affect the common consciousness: Thus, â€Å"†¦since the sentiments that crime offends within a single society are the most universally collective ones of all, since they represent especially powerful states of the common consciousness, they cannot possibly brook any opposition. †¦. e need a more violent form of satisfaction. † (p. 55) The kinds of offenses that give rise to repressive law assault transcendent values, â€Å"when we demand the repression of crime it is not because we are seeking a personal vengeance, but rather vengeance for something sacred which we vaguely feel is more or less outside and above us. † ( p. 56) At this point (right around p. 57 and 58), E. D. makes a subtle and important point. That punishing criminal activity reinforces the common consciousness. â€Å"Crime therefore draws honest consciousnesses together, concentrating them. † He provides an example.In a small town, everyone talks about the criminal scandal. Just like when horrible things happen in the news, we respond. By discussing the crime and punishment with people we know, we reinforce our opinion about the immorality of the action. â€Å"In short, since it is the common consciousness that is wounded, it must also be this that resists; consequently, resistance must be collective. † But why this resistance is organized remains to be explained. Historically, crimes were judged by the WHOLE people, then as society progressed, certain samples of people and judges took the place of the whole. bottom of p. 59) – the organization into courts is a division of labor response: the world got bigger, and needed more people to split up the work of policing the common consciousness. (Note, of course, that this is exactly the moment that greater individual variation in what, exactly, people have in common starts to magnify). â€Å"Thus, it is certainly the nature of the collective sentiments that accounts for punishment, and consequently for crime. † Organic Solidarity, on the other hand is characterized with the other type of law which is the restitutory law.Organic solidarity assumes that people are different from each other and they are interdependent with other forming a complex web of cooperative associations. Unlike the mechanical solidarity, the solidarity in this case is from each person cultivating individual differences and knowing that each one is doing something for the betterment of everyone. Moreover, Durkheim said that the organic solidarity arises only when the division of labor is spontaneous or voluntary. Because the division of labor is pushed too far the n it becomes dangerous for the individual for t may result to the isolation of in their special activity or skill. Thus making the division of labor a source of disintegration for the individuals and the society. *†Damages awarded have no penal character: they are simply a means of putting back the clock so as to restore the past, so far as possible, to its normal state. † (p. 69) †¢ Restitutory laws put the world back together — they restore what was before. †¢ Restitutory laws are not (usually) part of the collective common consciousness. Instead, they apply to very specific areas (corporate law, accounting law, housing law, contract law, etc. ) and, E. D. laims, a violation of such a law does not elicit the emotional need for expiation that a criminal offense does. â€Å"The idea that murder can be tolerates sets us up in arms, but we very readily accept that the law of inheritance might be modified, †¦. Since these prescriptions do not correspo nd to any feeling within us, an as generally we don no know their scientific justification, since this science does not yet exist, they have no deep roots in most of us. † [137] †¢ Since restitutory laws do not affect everyone, the solidarity that restitutory laws relate to cannot rest on a uniform similarity across everyone in the group. For Durkheim, organic solidarity refers to a type of solidarity in which each person is interdependent with others, forming a complex web of cooperative associations. In such situations, solidarity (or a feeling of â€Å"oneness†) comes not from each person believing/doing the same thing, but from each person cultivating individual differences and knowing that each is doing her part for the good of the whole. Thus, Durkheim argued that the increasing specialization and individuation so readily apparent in modern industrial societies does not necessarily result in a decline in social stability or cohesion.Rather, the growth in a so ciety’s density (the number of people living in a community) and consequent increasingly specialized division of labor can result in simply a different type of social cohesion. Abnormal Forms. (1) Anomic Division of Labor is cause by the lack of regulation or a weakened common morality that can occur in modern society. Usually surfaces when there are industrial or commercial crises or there are conflicts between capital and labor. Durkheim discusses conditions of the worker under capitalism and it somewhat very close to Marx’s description of lienation and exploitation. However, he says that situations like this are not in the normal form but is something resulting from an individual who does not have a sufficient vision of the whole process of production. (2) Forced Division of Labor is where the division of labor is not allowed to develop spontaneously and where some act to protect themselves and their positions. It is the consequence of a structural condition where t he distribution of social functions does not match to the distribution of natural talents. (3) Another Abnormal Form.Durkheim’s observation that the function of an organism can become more active only on the condition that they also become more continuous one organ can do more only if the other organs do more, and vice versa. When this continuity is missing then the functional activity of the specialized parts decreases, resulting in wasted effort and loss of productive capacity. Increased activity also results to a stronger bond of solidarity but when mismanagement arises, the activity of the worker is reduced, functions become discontinuous, and solidarity is destabilized.